News on Youtube Dec 8 2017

00:00:05:05] How did you feel about today's game? [00:00:08:21] After the world championship was over, [00:00:13:12] we came back and prepared for the KePSA cup during the off-season. [00:00:22:28] As you know, the game changed drastically [00:00:28:11] so it took some time getting adjusted to the new systems. [00:00:32:24] Because of that our play was a bit lacking, [00:00:36:11] even though we shouldn't be. [00:00:40:12] We are aiming to win the tournament [00:00:45:09 but Team Griffin turned out to be a formidable opponent. [00:00:50:19] Their strength has been rumored before and it proved to be true in today's game [00:00:54:02] by showing a high understanding of the new Meta. [00:00:57:23] In retrospective, it was a difficult match. [00:01:02:03] How was it playing with your new support, Effort, in his very first match? [00:01:02:03] Effort is very young and this was his first time playing as a pro. [00:01:21:15] Coach was talking to me about to reminisce when I started as a pro [00:01:27:23] and remember how nervous I was. [00:01:29:12] Because he came directly from solo queue to a team environment, [00:01:37:00] he must've been anxious. [00:01:39:08] So I was talking to him a lot to make him relax and talk about the game [00:01:43:19] to create an environment like at our practice house. [00:01:50:27 He is a player that will grow stronger in time [00:01:55:02] and I would've liked for him to perform his best on day one [00:01:59:03 and I think he performed admirably. [00:02:02:06] He didn't seem that perplexed and was able to play to his strengths [00:02:08:23 so it turned out well. [00:02:11:19] He shows great performance in solo queue [00:02:16:23] He has a kind personality and is very diligent during practice. [00:02:21:27] I feel he has nowhere but to go up at this point [00:02:26:20] and he will improve a lot in the future. [00:02:29:12] There was a lot of emphasis on Varus and Ashe [00:02:32:01] during the pick and ban phase this tournament. [00:02:33:22] Were those deliberate picks for your strategy? [00:02:40:12] To be honest, many of the picks were situational picks. [00:02:44:03] The opponent picked Miss Fortune which made us counter it [with Varus and Ashe]. [00:02:50:22] We have talked a lot about the possible pick ban scenarios. [00:03:03:20] If we don't pick Ashe or Varus, we end up in an unfavorable match up [00:03:10:03 where the opponent comes with a poke comp with Varus or Ashe. [00:03:14:22] That's why we picked Ashe and Varus. [00:03:17:25] For example, if I picked Varus, [00:03:20:21] the opponent might bring out a comp like Jhin & Miss Fortune or Ashe & Miss Fortune [00:03:29:25] which would've made the laning phase a bit difficult for me. [00:03:34:12] There were a lot of conflicts in terms of the possible matchup scenarios [00:03:37:05] so we picked Varus and Ashe as safe picks. [00:03:41:04] In the second set, your picks were Ashe and Xerath. [00:03:44:18] How did you feel about these picks? [00:03:47:25] I felt that we had a good early game during the laning phase, [00:04:01:28] but I over extended to take down the tower which led to giving them kills [00:04:07:21 which I was disappointed about. [00:04:09:14 The pick and draft wise, I think it was good. [00:04:13:03 But I felt the opponent had a bit more comfortable composition to work with [00:04:20:00] due to their longer auto attack range. [00:04:24:01]The opponent had a strong poking composition. [00:04:30:08] What went through your mind and what was it like facing them? [00:04:35:01] We had 2 strategies – dodge or have a tank champion absorb all the damage, [00:04:41:04] one of those two. [00:04:43:05] Either way both strategies were a defensive strategy [00:04:46:19] while the opponent had an offensive tactic. [00:04:48:22] I think the opponent had an easier time with this match. [00:04:54:04] Did you expect the second game to drag on as it did? [00:05:04:14] Whoever wins the longing phase and snowballs from it [00:05:09:16 determines the outcome of the game. [00:05:12:09] I expected the advantage from the laning phase will win the game, [00:05:18:07] but both sides had good defensive comps [00:05:22:12] and weren't able to siege the tower aggressively so it dragged on longer than expected. [00:05:34:24] With regards to your team roster, with 2 people leaving, [00:05:40:28] what are your thoughts on the roster change and how you feel? [00:05:47:00] If you think about it, we live, eat, sleep and play together for 1 year [00:05:59:08] and we're basically stuck together for that period and having the 2 members leave… [00:06:02:29] its common for players to leave and stay… [00:06:08:20] apart from the game, having younger brothers or older brothers leave, [00:06:17:29] it kind of hurts my heart seeing them go and I feel kind of sorry in some sense. [00:06:22:29] I feel like that sense still kind of exists right now. [00:06:27:14] Within the game, everyone works hard and prepares well to see better results. [00:06:33:19] we can expect to see better results than last year [with the new roster] [00:06:44:22] In regards to the members that left, I still miss them and when I see them my heart aches [00:06:50:10] but because they're on a different team and we have to face them, we still have to win. [00:06:56:21] Your next opponent can either be Longzhu or JinAir, [00:07:01:15] everyone thinks it will be Longzhu, [00:07:04:14] What goes in your head when thinking about going against Longzhu? Revenge perhaps? [00:07:11:06] or the specific preparation against them? [00:07:15:04]The first thing that comes across my mind is that Wang-ho (Peanut) went to Longzhu. [00:07:19:21] Even today we shared the same standby room, we still contact each other [00:07:24:09] and continue to contact each other. [00:07:26:18] And since he went to another team, we still have to compete and win against them [00:07:30:22] and in regards to Longzhu, even though they're a different team, [00:07:37:05 I have this expectation towards players and team. [00:07:41:04] With Longzhu, I personally didn't really like this team. [00:07:46:15] But now that Wang-ho (Peanut) is on this team, [00:07:53:15] before my interest level was here but now it's over here, [00:07:57:21] there is this aspect that it went higher. [00:08:00:28] Now, I have this high expectation of Longzhu if they make it. [00:08:05:02] And because it's the preseason, it's hard to tell how these teams will perform, [00:08:12:24] so there is a fun aspect. [00:08:16:14] Do you have any final messages for your fans? [00:08:20:04] If you look at this year, the World Cup ended, we still think this isn't the end of this year. [00:08:33:21] It may be a new start or end looking at KeSPA Cup. [00:08:38:09] Overall, we think it's a starting point for next year, to win, and have a good start for Spring. [00:08:52:19] Throughout KeSPA Cup, we want to show what it means to be SKT [00:09:00:26] and to show that we can bounce back. [00:09:05:01] So thank you for cheering us on and we'll do our best to show the best results.

For more infomation >> SKT T1 Bang on roster changes for 2018 & relationship with Peanut | KeSPA Cup 2017 Interview - Duration: 9:26.

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(December 7, 2017) A young man's relationship is tested by rumors of his girlfriend's indiscretions. - Duration: 39:20.

For more infomation >> (December 7, 2017) A young man's relationship is tested by rumors of his girlfriend's indiscretions. - Duration: 39:20.

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Brittany 😋 & Jax Almost Ruined My Relationship!😮Ariana Madix - Duration: 4:13.

Lisa Vanderpump and all of her messy TV children are back.

Vanderpump Rules ' season six premiere showed us a lot of drama ... including some "troubles"

between Jax Taylor and Brittany Cartwright.

Not to be outdone, Ariana Madix and Tom Sandoval have also been shown to be having relationship

struggles. And they're laying the blame for their issues directly at the feet of Jax and

Brittany.

Back when we first heard about Jax Taylor cheating on Brittany Cartwright , Tom Sandoval

seemed to try to distance himself from that narrative.

For a quick refresher:

Jax and Brittany have of course been together for ages, but Jax was accused of cheating

on her with Faith Stowers.

And then it appeared that Faith Stowers' period was late -- suggesting that she might be pregnant

with Jax's baby.

Both Ariana and Tom expressed disbelief.

As entertaining as most of us find the idea of Jax Taylor, of all people, being happily

monogamous for two years, it looks like at least some of his fellow Vanderpump Rules

stars believe that he's remained loyal to Ariana.

But while some believe that Jax has been faithful, others believed that he'd been filling Faith

.

(Sorry)

To no one's surprise, Katie Maloney was quick to bash Jax, suggesting that he should just

find a girl who won't mind his alleged cheating.

All caught up?

Well, Ariana Madix and Tom Sandoval were clearly also struggling in their relationship,

but we don't know where that storyline is going, exactly.

In an interview with TooFab , they try to explain a little about that without, you know,

spoiling their entire season's storyline on Vanderpump Rules .

They start off by talking about the drama between Jax and Brittany.

"We can't obviously give away too much," Ariana says. "But they are together now, as you can

see on social media ... it's a lot. "

You can hide a lot from social media, but people can pretty much tell if you're still

together or not.

(Also, and maybe this is a generational thing, but I love when people refer to something

as "a lot." It tells you that something will be intense and probably messy without giving

any details)

"So just gird your loins for that one."

That line could mean anything from "Faith fabricated a pregnancy just to destroy Brittany's

life!" to "Brittany is staying with Jax and has promised to help raise his lovechild once

Faith gives birth."

But, you know, probably something between those extremes.

Ariana then gets into how Jax and Brittany's problems weren't limited to each other.

"It's like a ripple effect."

That makes sense. 

"Anything that happens with any one couple, somehow ripples into all of the other people."

When a bunch of people are close, whether they're friends, family, frenemies, coworkers,

or costars, everyone's lives (and drama) can become interconnected.

And, specifically, Ariana says that she and Tom felt those effects.

"I think you see in the trailer that Tom and I went through some stuff so I'll go ahead

and say that that had something to do with it."

That is ... incredibly vague, Ariana.

But that's her job.

For a scripted series, actors play characters who aren't them at all, and are free to divulge

almost everything from their personal lives.

For a reality series, though, your personal lives are the storyline. You have to keep

personal details under wraps.

It it fair for Ariana and Tom to blame Jax and Brittany and that couple's "ripple effect"

for their own relationship problems?

Perhaps it will all make more sense once we've seen a lot more of this season.

37 Classic Vanderpump Rules Moments in GIFs

Start Gallery

For more infomation >> Brittany 😋 & Jax Almost Ruined My Relationship!😮Ariana Madix - Duration: 4:13.

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A CLOSER LOOK AT THE RELATIONSHIP BETWEEN MERCURY & CARDIOVASCULAR DISEASE - Duration: 15:02.

A CLOSER LOOK AT THE RELATIONSHIP BETWEEN MERCURY & CARDIOVASCULAR DISEASE

BY ROBERT F. KENNEDY JR.

Mercury�s toxic properties have been apparent for centuries.

Nonetheless, from the time of the first Emperor of China on, doctors have been fascinated

with the metal�s purported curative properties.

In the 19th and early 20th centuries, health practitioners blithely used mercury as a medical

treatment for everything from syphilis to teething discomfort to dysentery.

As early as the 1820s, some healers began to object to the practice of �giving poison

as medicine,� but, in many branches of medicine, physicians remained enthusiastic.

In the late 1890s, for example, the prestigious scientific journal The Lancet published case

studies broadcasting doctors� seemingly successful use of mercury for the treatment

of heart disease.

Referring to a mercurous chloride compound called calomel (also called the �blue pill�),

Dr. Arthur Foxwell in Birmingham praised, in September 1895, mercury�s �unique�

virtues as a cardiac tonic capable of �freeing� a sluggish heart of �half its labour.�

Although many researchers have focused heavily on mercury�s neurotoxicity in children,

others acknowledge that, in adults, the cardiovascular system may be exquisitely vulnerable to mercury�s

toxic effects.

Over a century later, the medical perspective on mercury and heart disease has come to look

quite different.

Although many researchers have focused heavily on mercury�s neurotoxicity in children,

others acknowledge that, in adults, the cardiovascular system may be exquisitely vulnerable to mercury�s

toxic effects.

A simple search using the terms �mercury� and �heart disease� in PubMed (the National

Institutes of Health database) pulls up ample documentation detailing a higher prevalence

of cardiovascular disease in individuals who have higher blood levels of mercury.

Mercury damages the cardiovascular system even at low concentrations of exposure.

Effects of Mercury on the Heart

Researchers who acknowledge that mercury exposure increases cardiovascular risk often profess

ignorance about the underlying cellular mechanisms of harm.

However, a trio of relatively recent articles makes it apparent that scientists actually

know quite a bit about how mercury exerts its cardiotoxic effects.

Two of the reports, published in 2011 in the Journal of Clinical Hypertension and in 2014

in the Journal of Cardiovascular Diseases & Diagnosis, are authored by Vanderbilt University

professor and hypertension expert Mark Houston, who has published extensively on hypertension

and heart disease since the 1980s.

Dr. Houston began turning his attention to the ramifications of mercury exposure for

heart disease a decade ago.

A newer study, a review by Italian researcher Giuseppe Genchi and colleagues that appeared

in the International Journal of Environmental Research and Public Health in 2017, also reviews

mercury�s overall toxicity and specific cardiovascular effects.

�the clinical consequences of these and other pathophysiologic mechanisms explain

the wide variety of cardiovascular diseases caused by mercury.�

It should not be surprising that many of the biological mechanisms that explain mercury�s

deleterious impacts on the brain (recently summarized here by World Mercury Project)

likewise create problems for the heart.

Dr. Houston�s two articles list 22 different vascular biological effects of mercury that

he further distills into the eight categories shown in the table below.

According to Houston, �the clinical consequences of these and other pathophysiologic mechanisms

explain the wide variety of cardiovascular diseases caused by mercury.� These conditions

include: hypertension, diastolic dysfunction, generalized atherosclerosis, coronary heart

disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, sudden cardiac

death, cerebrovascular accidents, carotid artery obstruction and left ventricular hypertrophy.

Vascular Biologic Effects of Mercury

Increased oxidative stress Vascular inflammation

Thrombosis Vascular smooth muscle proliferation and migration

Endothelial dysfunction Dyslipidemia (oxidation of high-density lipoprotein

and paraxonase) Immune dysfunction

Mitochondrial dysfunction SOURCES: Houston 2011 and Houston 2014

Increased oxidative stress: Mercury prompts increased production of free radicals (a type

of reactive oxygen species or ROS) and also inactivates antioxidant defenses, including

compromising the activity of the important antioxidant glutathione.

�Oxidative stress� is the term used to describe these disturbances in ROS equilibrium.

As Genchi and coauthors observe, �Glutathione�is the most potent intracellular and mitochondrial

antioxidant for protecting against oxidative stress, inflammation and cardiovascular diseases.�

In fact, clinicians consider increased oxidative stress as a predictive biomarkerfor cardiac

pathology: �When the finely regulated signaling pathways of [ROS] molecules become uninhibited,

it may lead to the initiation and progression of atherosclerotic disease.�

Vascular inflammation: Among its many inflammatory effects, mercury alters arachidonic acid metabolism.

Arachidonic acid metabolites are a type of fatty acid compound.

With mercury-induced inflammation, these metabolites make the vascular endothelium�which plays

a central role in vascular homeostasis�more �leaky.�

Thrombosis: Mercury induces thrombosis (blood clotting), in part, by promoting abnormal

coagulation and clumping of platelets as well as changes in platelet shape.

Back in 1946, clinicians who tested the suitability of mercury-containing gelatin solutions as

�plasma substitutes� in 39 patients initially were baffled to observe thrombosis of the

injected veins as a significant and frequent �untoward effect.� The physicians stated,

�Because of the high incidence and considerable extent of venous thrombosis it seemed likely

that the [gelatin] solutions contained a thrombosing substance�; they ultimately concluded that

the mercurial preservatives in the gelatin solutions were the �probable cause.�

Changes in vascular smooth muscle cells: Mercury stimulates proliferation and changes in the

size of vascular smooth muscle cells (VSMCs), versatile cells that line the walls of arteries

and veins.

VSMCs play a role �in all the physiological functions in the vascular wall,� including

regulation of blood pressure.

VSMCs are also �the main cellular determinants of arterial wall pathology.� Genchi et al.

point out that exposure to mercury compounds correlates strongly with hypertension.

Mercury�s effects on VSMCs have prompted calls to explicitly consider mercury as an

�environmental risk factor for cardiovascular disease.�

Endothelial dysfunction: The vascular endothelium is �indispensable for the regulation of

vascular tone and the maintenance of vascular homeostasis.� Even at very low levels of

exposure, mercury promotes endothelial dysfunction.

When the vascular endothelium stops working properly, it loses its ability to regulate

vascular tone and perform other essential jobs.

Clinicians consider endothelial dysfunction as an independent predictor of cardiac events

because it represents a �key early step in the development of atherosclerosis and�plaque

progression and the occurrence of atherosclerotic complications.�

Dyslipidemia: Heart disease experts have long viewed dyslipidemia (abnormal lipid profiles)

as closely related to coronary heart disease as well as metabolic syndrome.

Recent studies have confirmed that chronic exposure to organic mercury induces dyslipidemia

and contributes to the development of atherosclerotic plaques.

According to Dr. Houston and Genchi�s team, mercury disrupts lipids, in part, by inactivating

paraoxonase, an antioxidative enzyme that plays an important role in preventing cardiovascular

disease and atherosclerosis.

Paraoxonase is a major component of high-density lipoprotein (HDL), and mercury-induced inactivation

of paraoxonase, makes HDL cholesterol dysfunctional.

Immune dysfunction: Macrophages (a type of immune system cell called phagocytes) play

a key role in innate immunity by swallowing, killing and digesting invaders.

Exposure to mercury lowers immune function in part by reducing phagocytic activity.

Where cardiovascular disease is concerned, macrophages play a role �in both the progression

and regression of inflammation� in atherosclerotic lesions.

Researchers recently have noted the importance of understanding how pathological factors

such as mercury exposure affect macrophage activity so as to improve cardiovascular disease

outcomes.

A 2016 study by a group of European researchers, which found an association between a heart

condition called Takotsubo syndrome (TS) and �hypersensitivity� to mercury and other

metals, noted that TS patients displayed �pathological immune reactivity.�

Mitochondrial dysfunction: Scientists have extensively documented mercury�s adverse

effects on the mitochondria.

Toxicologists have shown that normal human brain cells, for example, preferentially take

up organic ethylmercury, damaging the cells� mitochondria and setting off a cascade that

leads to cell death.

The maladaptive mitochondrial responses triggered by mercury also play a major role in the development

of abnormalities related to cardiovascular disease, including dyslipidemia, hypertension

and various cardiac pathologies.

Chelation Therapy: At the close of their article, Genchi and coauthors recommend chelation therapy

as a strategy to get rid of mercury and thereby �avoid further distribution and penetration

[of mercury] in tissues.� Chelating agents bind to unwanted metals and minerals in the

blood and enable urinary excretion.

Clinicians started trying out the synthetic amino acid EDTA for the treatment of angina

and other forms of atherosclerotic disease beginning in the 1950s, after they observed

that EDTA not only chelated lead effectively but also improved and stabilized cardiovascular

function.

From 2003�2012, the National Institutes of Health funded the first large-scale study

of EDTA chelation therapy�the Trial to Assess Chelation Therapy (TACT)�to examine its

safety and efficacy in individuals who had experienced prior heart attacks.

Using a rigorous randomized placebo-controlled, double-blind study design, TACT found that

EDTA infusions safely reduced the risk of subsequent cardiac events, with particularly

pronounced therapeutic benefits in individuals with diabetes.

Commenting on what made the TACT study unique, investigators noted that whereas �the association

of metals with cardiovascular disease is not new�this knowledge has been held in [discipline-specific]

silos�[that] the cardiologist does not often visit.� They added that the TACT results

�have unveiled an exciting area of new�research with the underlying concept that xenobiotic

metals may be a modifiable risk factor for cardiovascular disease.�

The evidence base for EDTA is most substantial for lead and cadmium.

Genchi and coauthors describe other synthetic chelating agents, including DMSA and DMPS,

that can chelate and immobilize organic and inorganic forms of mercury, specifically.

However, dental expert Dr. Hal Huggins and cardiologist Dr. Thomas Levy (who coauthored

the book Uninformed Consent: The Hidden Dangers in Dental Care) discourage use of DMPS, which

they describe as a �sledge hammer to the immune system.� On the other hand, Huggins

and Levy view oral DMSA as acceptable, if used appropriately.

Studies have reported that children with autism spectrum disorder (ASD) also can benefit from

DMSA chelation therapy, which is not surprising given mercury�s role in contributing to

ASD.

One study carried out with 65 ASD children in the U.S. found that a single round of DMSA

had significant behavioral effects that correlated with increased excretion of mercury and other

toxic metals as well as changes in glutathione status.

Another studyinvolving 44 Egyptian children with ASD generated similar results.

Some autism expertshave urged caution in using overly aggressive synthetic chelation agents,

however.

Taking Mercury Seriously

Dr. Houston and Genchi�s team both comment on the sizeable body burden of mercury that

is accumulating in humans of our time (13 milligrams in the average 165-pound individual).

In light of the myriad �intake pathways� of mercury (via air, water, food, vaccines,

other pharmaceuticals and cosmetics), it behooves the public health community to take seriously

the relationship between mercury exposure and cardiovascular disease risks, particularly

because cardiovascular disease is the leading cause of death in the U.S. and around the

world.

At a minimum, it is vital that clinicians evaluate mercury toxicity �in any patient

with hypertension, coronary heart disease, cerebral vascular disease, or other vascular

diseases and in patients who have a clinical history of exposure or clinical evidence on

examination of mercury overload.�

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For more infomation >> A CLOSER LOOK AT THE RELATIONSHIP BETWEEN MERCURY & CARDIOVASCULAR DISEASE - Duration: 15:02.

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Robert Irvine Show (December 7, 2017) A young man's relationship is tested by rumors of his - Duration: 39:20.

For more infomation >> Robert Irvine Show (December 7, 2017) A young man's relationship is tested by rumors of his - Duration: 39:20.

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Carrie Fisher's sister Joely discusses their 'intense' relationship and ... - Duration: 2:49.

Carrie Fisher's sister Joely discusses their 'intense' relationship and experiences of abuse in Hollywood

Carrie Fishers sister appeared on ITVs Lorraine this morning and spoke about their complicated sibling relationship. Joely Fisher came on the show today (December 7) to talk to showbiz guru Ross King, almost a year after her famous sibling passed away.

Opening up about their relationship, she described it as intense and complex.

She said: I didnt get introduced to her – and I know that sounds odd but in our family that is how it was – but I didnt get introduced to her until after Star Wars came out.

We were 11 years apart and at that point, I did not have a relationship with her at all. However, after the introduction was made, Joely, together with her sister Tricia, developed a close relationship with Carrie.

As we grew older, we got invited in, she continued. It was an intense and complex relationship that was very important to me..

Carrie tragically passed away aged 60 on December 27, 2016, after suffering a cardiac arrest. The heart attack came on four days after it was reported she experienced a medical emergency on a transatlantic flight from London to Los Angeles.

I cant fathom that its been a year since she passed, Joely added. its like the world is off its axis..

Elsewhere during the interview, Joely was asked about the abuse scandal that has swept Hollywood this year.

Commenting on the bravery it has taken victims to speak out, she said: Its difficult being a young woman in this business. There are very powerful men out there.

We dont get to choose when we are harassed or abused. I have experienced it. Its very frightening and disarming..